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World J Gastroenterol. Jul 7, 2013; 19(25): 4007-4014
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4007
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4007
Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease
Lucia Pacifico, Sara Romaggioli, Flavia Ferraro, Stefano Bascetta, Department of Pediatrics, Sapienza University of Rome, 00161 Rome, Italy
Mario Bezzi, Concetta Valentina Lombardo, Department of Radiological Sciences, Sapienza University of Rome, 00161 Rome, Italy
Claudio Chiesa, Institute of Translational Pharmacology, National Research Council, 00133 Rome, Italy
Author contributions: Pacifico L and Chiesa C designed the study, analyzed the data and wrote the manuscript; Romaggioli S, Ferraro F and Bascetta S collected the data; Bezzi M and Lombardo CV performed the measurements and analyses; all the authors participated in the critical review and in the final approval of the manuscript.
Supported by A Grant from Sapienza University of Rome, Progetti di Ricerca Universitaria 2010-2011
Correspondence to: Claudio Chiesa, MD, Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere, 00133 Rome, Italy. claudio.chiesa@ift.cnr.it
Telephone: +39-6-49979215 Fax: +39-6-49979216
Received: February 13, 2013
Revised: April 2, 2013
Accepted: April 18, 2013
Published online: July 7, 2013
Revised: April 2, 2013
Accepted: April 18, 2013
Published online: July 7, 2013
Core Tip
Core tip: Understanding the mechanisms underlying the relationship between nonalcoholic fatty liver disease (NAFLD) and low bone mineral density (BMD) is important to prevent poor bone mineralization in obese children. We showed that obese children with NAFLD have decreased BMD compared to obese children without liver involvement independently of adiposity, and that children with more severe histology have worse mineral status than children with more mild abnormalities. We also found a significant independent association of high sensitivity C-reactive protein with BMD scores, supporting the role of an inflammatory state which may accelerate loss of bone mass in patients with NAFLD.