Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 7, 2013; 19(25): 3969-3979
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3969
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3969
Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells
Shi-Hai Xia, Xiao-Hui Xiang, Kai Chen, Wei Xu, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital of the Logistics University of the Chinese People’s Armed Police Force, Tianjin 300162, China
Author contributions: Xiang XH and Chen K contributed equally to this work; Xia SH contributed to the conception of this study; Xia SH, Xiang XH, Chen K and Xu W designed the research strategy and performed the experiments; Xia SH and Xiang XH performed the data analysis and interpretation; Xiang XH, Chen K and Xu W prepared the manuscript; Xia SH revised the manuscript.
Supported by The National Natural Science Foundation of China, No. 81173393; the Natural Science Foundation of Tianjin City, Grant No. 12YFJZJC00800; the Scientific Research Foundation for PhD grant to Xia SH, No. WYB201010; and the Innovation Team Program (WHTD201310) from the Logistics University of the Chinese People’s Armed Police Force
Correspondence to: Shi-Hai Xia, MD, PhD, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital of the Logistics University of the Chinese People’s Armed Police Force, 220 Chenglin Road, Hedong District, Tianjin 300162, China. xshhcx@sina.com
Telephone: +86-22-60577731 Fax: +86-22-24370605
Received: December 19, 2012
Revised: June 5, 2013
Accepted: June 8, 2013
Published online: July 7, 2013
Revised: June 5, 2013
Accepted: June 8, 2013
Published online: July 7, 2013
Core Tip
Core tip: Microcirculatory disorder is considered to be one of the possible mechanisms of pathogenesis of severe acute pancreatitis (SAP). Platelet-activating factor (PAF) is known to mediate microcirculatory disturbance and inflammation. Although BN52021, a PAF receptor antagonist, has demonstrated significant treatment effects on SAP, its mechanism has not been elucidated in detail. In this study, we examined the signaling molecules of the PAF receptor pathway to evaluate whether BN52021 has any influence on the inflammatory effects induced by lipopolysaccharide in MS1 cells, hoping to elucidate the mechanism underlying microcirculatory disturbances in the pathogenesis of SAP in vitro.