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World J Gastroenterol. Jun 28, 2013; 19(24): 3861-3865
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3861
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3861
Relationship between hepatocellular carcinoma and hepatitis B virus genotype with spontaneous YMDD mutations
Jia-Hong Yang, Hao Zhang, Xue-Bing Chen, Gao Chen, Xiu Wang, Department of Infectious Diseases, People’s Hospital of Deyang City, Deyang 618000, Sichuan Province, China
Author contributions: Yang JH designed the research and wrote the manuscript; Zhang H prepared the manuscript; Chen XB analyzed data and prepared the manuscript; Chen G and Wang X performed experiment.
Supported by Health Bureau of Sichuan Province, China, No. 070283 and 100175
Correspondence to: Jia-Hong Yang, MD, Department of Infectious Diseases, People’s Hospital of Deyang City, No. 173, Taishan North Road, Deyang 618000, Sichuan Province, China. 18990283956@163.com
Telephone: +86-838-2418636 Fax: +86-838-2220098
Received: February 6, 2013
Revised: April 12, 2013
Accepted: May 7, 2013
Published online: June 28, 2013
Revised: April 12, 2013
Accepted: May 7, 2013
Published online: June 28, 2013
Core Tip
Core tip: YMDD mutation is a research hotspot globally. Until recently, most research about YMDD mutation focused on the occurrence of lamivudine-related YMDD mutation and its impact on antiviral treatment. In our research, 264 hepatitis B virus (HBV)-related liver cirrhosis patients not treated with antiviral drugs, including 81 with primary hepatocellular carcinoma (HCC), were investigated for the association between infection by different HBV genotype strains with spontaneous YMDD mutations and occurrence of primary HCC in cirrhosis patients. Infection by genotype C strains with spontaneous YMDD mutations is an independent risk factor for the development of HCC in cirrhosis patients.