Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 28, 2013; 19(24): 3792-3801
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3792
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3792
Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells
Hai-Jian Zhang, Deng-Fu Yao, Min Yao, Li Wang, Mei-Juan Yan, Wei Wu, Shao-Lin Lu, Research Centre of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Hua Huang, Department of Pathology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Xiao-Di Yan, Xing Gu, Department of Clinical Oncology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Zhang HJ and Yao M contributed equally to this work, designed the research study, conducted the experiments, analysed the data, and wrote the paper; Wang L, Yan MJ and Gu X carried out the in vitro experiments; Wu W and Yan XD performed the in vivo experiments; Huang H conducted the immunohistochemical and hematoxylin and eosin staining analyses; Lu SL critically reviewed the manuscript; Yao DF is the guarantor.
Supported by The Society Development of Nantong, No. HS2012034; the Jiangsu Health Projects, No. BL2012053 and No. K201102; the Priority Academic Program Development of Jiangsu, and the International S and T Cooperation Program of China, No. 2013DFA32150
Correspondence to: Deng-Fu Yao, MD, PhD, Professor, Research Centre of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Telephone: +86-513-85052297 Fax: +86-513-85052254
Received: March 13, 2013
Revised: April 30, 2013
Accepted: May 18, 2013
Published online: June 28, 2013
Revised: April 30, 2013
Accepted: May 18, 2013
Published online: June 28, 2013
Core Tip
Core tip: The overexpression of annexin A2 (ANXA2) is closely related to the high metastasis potential and invasion ability of HCC cells, and ANXA2 deficiency inhibits the invasion, migration, and tumorigenic potential of hepatocellular carcinoma (HCC) cells, which not only provides further insight into the pathogenesis of HCC but also provides a potential predictive biomarker for HCC prognosis and a potential therapeutic target.