Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3602
Revised: April 1, 2013
Accepted: April 18, 2013
Published online: June 21, 2013
Core tip: In the gastrointestinal tract melatonin is secreted mainly by enterochromaffin cells (EC). It appears that hydroxyindole-O-methyltransferase (HIOMT) is enzyme determining melatonin synthesis. This indoleamine exert, antioxidant, and anti-inflammatory effects. Its synthesis can be disturbed by pro-inflammatory cytokines. The obtained results noted the proliferation of EC cells and the increase of HIOMT expression in ulcerative colitis ulcerative colitis (UC). Positive correlation between the amount of EC cells and urinary 6-sulfatoxymelatonin excretion points to the increase of melatonin secretion in the colon, but its beneficial anti-inflammatory effect was insufficient. The results indicate that the supplementation of melatonin may be useful in complex treatment of UC.