Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3534
Revised: May 10, 2013
Accepted: May 18, 2013
Published online: June 21, 2013
Core tip: From the literature data it is clear that obesity in humans affects different compartments of immune system. The aim of this review is to let clinicians appreciate the new role of metabolic and endocrine functions of the spleen with special emphasis to obesity and nonalcoholic fatty liver disease in the context of the available literature. Moreover, understanding the spleen function could be important to develop appropriate prevention strategies in order to counteract the pandemia of obesity. In this direction, we suggest spleen longitudinal diameter at ultrasonography, as simple, cheap and largely available tool, be used as new marker for assessing the liver/spleen axis.