Case Report
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 14, 2013; 19(22): 3502-3504
Published online Jun 14, 2013. doi: 10.3748/wjg.v19.i22.3502
Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia
Barun Kumar Lal, Adrian Stanley
Barun Kumar Lal, Adrian Stanley, Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow G4 0SF, United Kingdom
Author contributions: Lal BK designed and wrote the case report; Stanley A chose the case and gave valuable ideas throughout the case report writing.
Correspondence to: Dr. Barun Kumar Lal, MBBS, MRCP, Clinical fellow in Gastroenterology, 2 Dorset Square, Glasgow G4 0SF, United Kingdom.
Telephone: +44-141-2210532 Fax: +44-141-2115131
Received: November 20, 2012
Revised: January 30, 2013
Accepted: February 5, 2013
Published online: June 14, 2013
Core Tip

Core tip: Nodular regenerative hyperplasia (NRH) is still an evolving concept. Although a rarely identified liver disorder, it is a frequent cause of noncirrhotic portal hypertension. Liver involvement in primary hypogammaglobulinemia mainly consists of NRH leading to chronic cholestasis and portal hypertension. Optimal management of gastric variceal bleed remains unclear. Histoacryl injection is the endoscopic method of choice for gastric variceal bleed but one should keep a lower threshold for transjugular intrahepatic portosystemic shunt procedure for recurrent gastric variceal bleed.