Published online Jun 14, 2013. doi: 10.3748/wjg.v19.i22.3502
Revised: January 30, 2013
Accepted: February 5, 2013
Published online: June 14, 2013
Core tip: Nodular regenerative hyperplasia (NRH) is still an evolving concept. Although a rarely identified liver disorder, it is a frequent cause of noncirrhotic portal hypertension. Liver involvement in primary hypogammaglobulinemia mainly consists of NRH leading to chronic cholestasis and portal hypertension. Optimal management of gastric variceal bleed remains unclear. Histoacryl injection is the endoscopic method of choice for gastric variceal bleed but one should keep a lower threshold for transjugular intrahepatic portosystemic shunt procedure for recurrent gastric variceal bleed.