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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 21, 2013; 19(19): 2956-2962
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2956
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2956
Intraperitoneal perfusion of cytokine-induced killer cells with local hyperthermia for advanced hepatocellular carcinoma
Xiao-Pu Wang, Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou 510620, Guangdong Province, China
Xiao-Pu Wang, Department of Oncology, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou 511495, Guangdong Province, China
Meng Xu, Hong-Fei Gao, Jian-Fu Zhao, Department of Oncology, the First Affiliated Hospital of Jinan University, Guangzhou 510620, Guangdong Province, China
Ke-Cheng Xu, Fuda Cancer Hospital, Jinan University, Guangzhou 510630, Guangdong Province, China
Author contributions: Wang XP and Xu M contributed equally to this work; Xu M and Xu KC designed research; Wang XP and Xu M performed research; Zhao JF provided new reagents or analytic tools; Gao HF analyzed data; Wang XP and Xu M wrote the paper.
Supported by The National Natural Science Foundation of China, No.81273814
Correspondence to: Meng Xu, MD, Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou 510620, Guangdong Province, China. xumengjinan@yahoo.com
Telephone: +86-20-38993900 Fax: +86-20-38688000
Received: January 23, 2013
Revised: March 24, 2013
Accepted: April 10, 2013
Published online: May 21, 2013
Revised: March 24, 2013
Accepted: April 10, 2013
Published online: May 21, 2013
Core Tip
Core tip: Intraperitoneal perfusion of cytokine-induced killer (CIK) cells in combination with local radio frequencyc hyperthermia can result in a high concentration of CIK cells. This treatment can efficiently improve immunological status, and attack small lesions in the abdominal wall, which can reduce ascites and relieve abdominal distention. This comprehensive treatment may prolong survival time and improve quality of life in patients with advanced hepatocellular carcinoma.