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World J Gastroenterol. May 21, 2013; 19(19): 2847-2863
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2847
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2847
Chemokines, chemokine receptors and the gastrointestinal system
Hiroshi Miyazaki, Kazuaki Takabe, W Andrew Yeudall, Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, United States
Hiroshi Miyazaki, W Andrew Yeudall, Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, United States
Hiroshi Miyazaki, W Andrew Yeudall, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States
Kazuaki Takabe, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, United States
Author contributions: All the authors generated the ideas and contributed to the writing of this paper.
Correspondence to: Hiroshi Miyazaki, MD, PhD, Assistant Professor, Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University School of Dentistry, PO Box 980566, 520 N 12th St, Richmond, VA 23298, United States. hmiyazaki@vcu.edu
Telephone: +1-804-8271766 Fax: +1-804-8280150
Received: September 12, 2012
Revised: March 22, 2013
Accepted: April 27, 2013
Published online: May 21, 2013
Revised: March 22, 2013
Accepted: April 27, 2013
Published online: May 21, 2013
Core Tip
Core tip: The chemokine network makes an attractive target for therapeutic intervention in many tumor types, including those of the gastrointestinal tract. However, we need to define more selective and specific targets, to minimize systemic side effects during treatment.