Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2793
Revised: March 8, 2013
Accepted: March 15, 2013
Published online: May 14, 2013
Core tip: This study represents one of the longest follow-up studies on the natural history of successfully treated chronically hepatitis C virus (HCV) infected individuals. The outcome of the study was very positive, as it revealed an extremely high survival rate, an extremely low rate of liver complications, and a significant reduction in liver fibrosis in patients who have achieved sustained virological response (SVR). All of the patients without cirrhosis before starting the treatment showed no signs of evolution or decompensation over the years of observation, proving that SVR positively changes the natural history in individuals with HCV-infection.