Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2781
Revised: March 27, 2013
Accepted: April 10, 2013
Published online: May 14, 2013
Core tip: Our previous study revealed that mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD binding protein (MAWBP), acting as a complex, were differentially expressed in gastric cancer (GC) tissues compared with that in normal gastric tissues. The present study provided direct evidence that MAWBP and MAWD inhibited proliferation and migration of GC cells. Importantly, interaction of MAWBP and MAWD influenced expression of epithelial-mesenchymal transition (EMT) markers induced by transforming growth factor (TGF)-β1 in GC cells. It indicated that coexpression of MAWBP and MAWD inhibited TGF-β1-induced EMT, thus suppressing EMT-aided GC malignant progression.