Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2761
Revised: February 11, 2013
Accepted: February 28, 2013
Published online: May 14, 2013
Core tip:α-lipoic acid (LA), a potent antioxidant and also an inducer of endogenous antioxidants has been reported to protect the liver and pancreas from injury. Our observations suggest that LA could significantly suppress inflammatory change of steatosis induced by low-dose intraportal lipopolysaccharide infusion and associated deterioration of insulin secretion in this metabolic syndrome rodent model. In addition, our data suggest that hepatic toll-like receptor 4 signaling might not only play a significant role in chronic fructosefeeding-induced hepatic steatosis but also in its subacute inflammatory change induced by mild portal endotoxemia and associated extrahepatic disorders.