Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2073
Revised: January 28, 2013
Accepted: February 5, 2013
Published online: April 7, 2013
Core tip: Galectin-1 and vascular endothelial growth factor (VEGF) played important roles in angiogenesis and progression of malignant tumor, while their expression in Chinese gastric cancer and relationship between the two parameters and clinicopathological features, as well as prognostic value remained largely unknown. In this present study, we examined 214 gastric cancer samples for the presence of galectin-1 oncoprotein and VEGF by immunohistochemistry and found that overexpressions of galectin-1 and VEGF were related with tumor progression and poor survival, and our findings supported an association between galectin-1 and VEGF expression. These two molecules may serve as independent predicative markers for patient prognosis in gastric cancer.