Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2065
Revised: January 25, 2013
Accepted: February 5, 2013
Published online: April 7, 2013
Core tip: Portal hypertension (PHT) is a life-threatening condition which frequently develops in patients with liver cirrhosis, and has limited treatment options. For many years, endothelin-1 (ET-1) has received considerable interest in the area of liver cirrhosis for its potential contribution to PHT. The aim of the present study was to directly examine the expression of ET-1 and its receptors in the mesentery of rats with PHT, and to clarify how the ET-1 signaling system changed with the development of PHT.