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World J Gastroenterol. Jul 14, 2011; 17(26): 3117-3125
Published online Jul 14, 2011. doi: 10.3748/wjg.v17.i26.3117
Published online Jul 14, 2011. doi: 10.3748/wjg.v17.i26.3117
Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism
Jesper AB Strickertsson, Kristina BV Døssing, Anna JM Aabakke, Thomas VO Hansen, Lennart Friis-Hansen, Genomic Medicine, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
Jesper AB Strickertsson, Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark
Hans-Olof Nilsson, Torkel Wadström, Department of Microbiology, University of Lund, Lund, Sweden.
Ulrich Knigge, Department of Gastro-Intestinal Surgery, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
Andreas Kjær, Department of Clinical Physiology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
Author contributions: Strickertsson JAB designed the study, performed the promoter studies, and wrote the paper; Døssing KBV provided the cell lines; Aabakke AJM performed the immunohistochemical analysis; Nilsson HO designed the infection studies, handled the bacterial cultures, performed the infection studies, and interpreted the data; Hansen TVO designed and supervised the promoter study; Knigge U provided the wt and HDC KO mice; Kjær A provided the wt and HDC KO mice; Wadström T designed the study, provided the bacterial cultures, supervised the experiments, interpreted the data, and wrote the paper; Friis-Hansen L designed the study, provided the wt and gastrin KO mice, supervised the experiments, interpreted the data, and wrote the paper.
Supported by The Danish MRC Grant 271-08-0378 (LFH), the ALF grant (TW), The Lundbeck foundation (KBVD)
Correspondence to: Lennart Friis-Hansen, MD, DMSc, Genomic Medicine, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, KB-3014, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. lfh@rh.dk
Telephone: +45-35-455509 Fax: +45-35-454640
Received: December 21, 2010
Revised: March 5, 2011
Accepted: March 12, 2011
Published online: July 14, 2011
Revised: March 5, 2011
Accepted: March 12, 2011
Published online: July 14, 2011
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