NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients

doi:10.3748/wjg.v16.i41.5233

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Nov 7, 2010 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2010; 16(41): 5233-5240
Published online Nov 7, 2010. doi: 10.3748/wjg.v16.i41.5233

NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients

Nora Meggyesi, Lajos S Kiss, Magdalena Koszarska, Martin Bortlik, Dana Duricova, Laszlo Lakatos, Tamas Molnar, Martin Leniček, Libor Vítek, Istvan Altorjay, Maria Papp, Zsolt Tulassay, Pal Miheller, Janos Papp, Attila Tordai, Hajnalka Andrikovics, Milan Lukas, Peter Laszlo Lakatos

Nora Meggyesi, Magdalena Koszarska, Attila Tordai, Hajnalka Andrikovics, Department of Molecular Diagnostics, Hungarian National Blood Transfusion Service, H-1113 Budapest, Hungary

Lajos S Kiss, Janos Papp, Peter Laszlo Lakatos, 1st Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary

Martin Bortlik, Dana Duricova, Milan Lukas, IBD Clinical and Research Centre, ISCARE IVF and 1st Medical Faculty, Charles University, 170 04 Prague, Czech Republic

Laszlo Lakatos, 1st Department of Medicine, Csolnoky F. County Hospital, H8200 Veszprem, Hungary

Tamas Molnar, 1st Department of Medicine, University of Szeged, H6720 Szeged, Hungary

Martin Leniček, Libor Vítek, Department of Biochemistry and Laboratory Diagnostics, 1st Medical Faculty, Charles University, 170 04 Prague, Czech Republic

Istvan Altorjay, Maria Papp, 2nd Department of Medicine, University of Debrecen, H4032 Debrecen, Hungary

Zsolt Tulassay, Pal Miheller, 2nd Department of Medicine, Semmelweis University, H1085 Budapest, Hungary

Author contributions: Meggyesi N, Koszarska M, Tordai A and Andrikovics H carried out genetic analysis and data analysis, collection and validation of patients, and manuscript preparation; Leniček M and Vítek L provided the DNA samples for the Czech patients and controls, and helped with manuscript preparation; Kiss LS, Bortlik M, Duricova D, Lakatos L, Molnar T, Altorjay I, Papp M, Tulassay Z, Miheller P, Papp J and Lukas M performed data collection and manuscript preparation; Lakatos PL was responsible for study design, data collection, data analysis, collection and validation of patients, and manuscript preparation.

Supported by An unrestricted research grant from Abbott Laboratories; an OTKA postdoctoral fellowship (PF63953) (to Andrikovics H); the Bolyai Janos Postdoctoral Scholarship of the Hungarian Academy of Sciences (to Lakatos PL); No. NR/9219-3/2007 of the Internal Grant Agency of the Czech Ministry of Health (to Lukas M); Generation of the Czech IBD as well as control databases was enabled by the support of a grant given by the Czech Ministry of Education No. 2B06155

Correspondence to: Peter Laszlo Lakatos, MD, PhD, 1st Department of Medicine, Semmelweis University, Koranyi st. 2/A, H-1083 Budapest, Hungary. kislakpet@bel1.sote.hu

Telephone: +36-1-2100278 Fax: +36-1-3130250

Received: July 1, 2010
Revised: August 2, 2010
Accepted: August 9, 2010
Published online: November 7, 2010

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