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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
Miao-Miao Zhang, Guang-Bin Zhao, Han-Zhi Zhang, Shu-Qin Xu, Ai-Hua Shi, Jian-Qi Mao, Jing-Ci Gai, Yu-Han Zhang, Jia Ma, Yun Li, Yi Lyu, Xiao-Peng Yan
Miao-Miao Zhang, Shu-Qin Xu, Yun Li, Yi Lyu, Xiao-Peng Yan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Miao-Miao Zhang, Shu-Qin Xu, Ai-Hua Shi, Yi Lyu, Xiao-Peng Yan, National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Guang-Bin Zhao, State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China
Han-Zhi Zhang, Jing-Ci Gai, Yu-Han Zhang, Qide College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Jian-Qi Mao, Zonglian College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Jia Ma, Department of Surgical Oncology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China
Author contributions: Lyu Y and Yan XP designed and coordinated the study; Zhang MM, Zhao GB, Zhang HZ, Xu SQ, Mao JQ, Zhang YH, Ma J, Li Y, Yan XP performed the research and acquired the data; Zhang MM, Zhao GB, Zhang HZ analyzed the data; Shi AH, Zhao GB, Zhang MM tested and analyzed the magnetic test; Zhang MM, Zhao GB, and Yan XP wrote the manuscript; Yan XP and Lyu Y conceived of the study and contributed to the study design, the interpretation of the results, and the critical revision of the manuscript; all authors read and approved the final manuscript.
Supported by the Institutional Foundation of The First Affiliated Hospital of Xi’an Jiaotong University, No. 2022MS-07; the Key Research & Development Program-Social Development of Shaanxi Province of China, No. 2023-YBSF-247.
Institutional review board statement: The experimental protocol was approved by the Committee for Ethics of Animal Experiments of Xi’an Jiaotong University (No. 2022-1451).
Institutional animal care and use committee statement: The study protocol and all experimental procedures were carried out strictly in accordance with the Guidelines for Care and Use of Experimental Animals issued by the Xi’an Jiaotong University Medical Center. This experimental study was approved by the Experimental Ethics Committee of Xi’an Jiaotong University (No. 2022-1451).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors declare that the data supporting the findings of this study are available within the article or from the corresponding authors upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xiao-Peng Yan, MD, PhD, Associate Research Scientist, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. yanxiaopeng9966@163.com
Received: June 14, 2023
Peer-review started: June 14, 2023
First decision: August 5, 2023
Revised: August 7, 2023
Accepted: August 15, 2023
Article in press: August 15, 2023
Published online: September 7, 2023
ARTICLE HIGHLIGHTS
Research background
Magnetic compression anastomosis, or magnamosis, has been widely used for anastomotic recanalization of gastrointestinal stenosis. At present, the magnets applied to the digestive tract lumen anastomosis are usually cylindrical or circular.
Research motivation
In order to achieve magnetic anastomosis recanalization through a single-access natural orifice, we designed a deformable self-assembled magnetic anastomosis ring (DSAMAR). It is expected to provide a more minimally invasive treatment method for patients with colonic stenosis.
Research objectives
To verify the feasibility and safety of using DSAMAR to recanalize colonic stenosis through the single-approach natural orifice.
Research methods
Colonic stricture models were established in 8 beagle dogs. DSAMAR was used to achieve magnamosis recanalization of colonic stenosis and evaluate the formation of colonic anastomosis.
Research results
The results showed that the use of DSAMAR for recanalization of colonic stenosis was feasible and the anastomosis formation was good.
Research conclusions
The feasibility and safety of using DSAMAR to achieve colonic stenosis recanalization through a single-approach natural orifice were verified through animal experiments.
Research perspectives
The design of DSAMAR is ingenious. In addition to colon stenosis, it can also be used for minimally invasive treatment of digestive tract stenosis such as esophageal stricture and duodenal obstruction. It could provide a more minimally invasive treatment for patients with gastrointestinal stenosis.
