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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2022; 28(7): 715-731
Published online Feb 21, 2022. doi: 10.3748/wjg.v28.i7.715
Clinical online nomogram for predicting prognosis in recurrent hepatolithiasis after biliary surgery: A multicenter, retrospective study
Tian Pu, Jiang-Ming Chen, Zi-Han Li, Dong Jiang, Qi Guo, Ang-Qing Li, Ming Cai, Zi-Xiang Chen, Kun Xie, Yi-Jun Zhao, Cheng Wang, Hui Hou, Zheng Lu, Xiao-Ping Geng, Fu-Bao Liu
Tian Pu, Jiang-Ming Chen, Zi-Han Li, Dong Jiang, Qi Guo, Ang-Qing Li, Zi-Xiang Chen, Kun Xie, Yi-Jun Zhao, Xiao-Ping Geng, Fu-Bao Liu, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Ming Cai, Cheng Wang, Department of General Surgery, The First Affiliated Hospital of the University of Science and Technology of China, Hefei 230001, Anhui Province, China
Hui Hou, Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Zheng Lu, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233030, Anhui Province, China
Author contributions: Pu T, Chen JM, Li ZH, and Jiang D contributed to the data analysis and participated in drafting the article; Guo Q, Li AQ, and Cai M extracted the clinical data and calculated the clinical correlations; Chen ZX, Xie K and Zhao YJ interpreted the results and revised the manuscript; Liu FB, Hou H, Lu Z, Wang C, and Geng XP gave final approval of the version to be published; and all authors contributed to the design and interpretation of the study and to further drafts and approved the final version to be published.
Supported by the Key Research and Development Plan of Anhui Province, No. 1804h08020239.
Institutional review board statement: The study was reviewed and approved by the Institutional ethics committees of the First Affiliated Hospital of Anhui Medical University (Approval No: Quick-PJ2021-08-19).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: We have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Fu-Bao Liu, MD, PhD, Chief Doctor, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Hefei 230022, Anhui Province, China. lancetlfb@126.com
Received: September 14, 2021
Peer-review started: September 14, 2021
First decision: November 7, 2021
Revised: November 20, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: February 21, 2022
ARTICLE HIGHLIGHTS
Research background
Hepatolithiasis is a refractory benign disease with high recurrence rate. Many patients have poor prognosis.
Research motivation
There have been no large studies of patients with hepatolithiasis, and there are no clear risk factors for prognosis in these patients.
Research objectives
We aimed to find the risk factors affecting the prognosis of these patients and establish a prediction model which is conducive to clinical surgical decision-making.
Research methods
We collected data of hepatolithiasis patients in four large medical centers, identified independent risk factors and established nomogram. And then we used the concor-dance index, calibration, area under curve, decision curve analysis, clinical impact curves, and visual fit indices to evaluate the accuracy of the nomogram.
Research results
Multiple previous surgeries, bilateral hepatolithiasis, absence of immediate clearance, neutrophil-to-lymphocyte ratio ≥ 2.462, and albumin-to-globulin ratio ≤ 1.5 were found to be independent factors influencing the prognosis. And our nomogram has a higher predictive value than traditional classifications.
Research conclusions
A nomogram for predicting the prognosis of patients with recurrent hepatolithiasis was established for the first time, and an online calculator was set up to help surgeons make clinical decisions.
Research perspectives
More medical centers included, more data collection, and application of “Artificial Intelligence”.
