Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3913
Peer-review started: February 9, 2021
First decision: March 28, 2021
Revised: April 10, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: July 7, 2021
There are complex interactions between Helicobacter pylori (H. pylori) and other microbial communities in the gastric microecological environment. Yet, it remains unclear whether the interactions affect the eradication of H. pylori.
The motivation was to explore the interaction between gastric microbiota and H. pylori and to determine the influence of gastric microbiota on the eradication of H. pylori.
To investigate the characteristics of the gastric mucosa microbiota with H. pylori infection and the influence on H. pylori eradication treatment. This may help improve the eradication rate of H. pylori in the future.
Patients with H. pylori infection underwent gastroscopy and received treatment. Propensity matching analysis was conducted, including the number of patients who did not respond to treatment. The gastric microbiota was assayed by high-throughput sequencing and subsequent analysis of alpha diversity, beta diversity, species correlations, and predicted metabolic pathways.
The main phyla in the two groups were the same in the eight failure group patients who did not respond well to therapy and the 16 success group patients and included Proteobacteria, Bacteroides, Firmicutes, Actinomycetes, and Fusobacteria. The high rate of H. pylori eradication was associated with Rhodococcus, Lactobacillus, and Sphin
The effectiveness of quadruple H. pylori eradication therapy containing bismuth depended on the gastric microbiota. The high rate of H. pylori eradication was associated with Rhodococcus, Lactobacillus, and Sphingomonas.
This study laid a foundation for further research on the mechanism of the influence of the gastric microbiota on H. pylori eradication, which will help to improve the eradication rate of H. pylori in the future.