Published online Aug 14, 2020. doi: 10.3748/wjg.v26.i30.4523
Peer-review started: April 20, 2020
First decision: May 15, 2020
Revised: May 26, 2020
Accepted: July 23, 2020
Article in press: July 23, 2020
Published online: August 14, 2020
No studies have evaluated the predictive value of alarm symptoms for organic dyspepsia and organic upper gastrointestinal (GI) diseases based on Rome IV criteria in the Chinese population.
Previous studies have shown that the sensitivity of alarm symptoms for predicting cases with upper GI malignancies is unsatisfactory. The predictive value of alarm symptoms requires further research.
To evaluate the predictive value of alarm symptoms of dyspeptic patients based on Rome IV criteria.
We performed a cross-sectional study of dyspepsia patients who met the inclusion and exclusion criteria from March 2018 to January 2019.
Based on the Rome IV criteria, alarm symptoms were of limited value in differentiating organic dyspepsia and organic upper GI diseases from functional dyspepsia.
Most alarm symptoms had poor predictive value for organic dyspepsia and organic upper GI diseases based on Rome IV criteria. The clinical characteristics of patients with epigastric pain syndrome, postprandial distress syndrome and the two combined were not significantly different.
Gastroscopic screening of dyspepsia patients should not be based solely on alarm symptoms. In the future, the predictive value of alarm symptoms still needs to be confirmed by larger sample studies from multicenters all over China.