Published online Apr 7, 2020. doi: 10.3748/wjg.v26.i13.1474
Peer-review started: December 4, 2019
First decision: January 16, 2020
Revised: February 4, 2020
Accepted: March 9, 2020
Article in press: March 9, 2020
Published online: April 7, 2020
Recently, colon cancer (CC) has displayed a high incidence, and the main treatment of CC is chemotherapy. Oxaliplatin (L-OHP) is a common drug used in chemotherapy, but long-term use can result in drug resistance, seriously affecting the prognosis of patients.
Long non-coding RNA Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) appears to be up-regulated, which plays a tumor-promoting role in a number of cancers. It is speculated that miR-137 may be effective in mediating drug resistance in CC cells.
To determine the effect of long non-coding RNA OIP5-AS1 on drug resistance in CC cell lines and its role in regulating miR-137.
We not only analyzed the expression levels of OIP5-AS1 and miR-137 in surgical CC tissue samples, but also observed their effects on the biological behavior of CC cells as well as L-OHP resistance.
We noted high expression of OIP5-AS in CC tissues and cells and low expression of miR-137. In cytological studies, it was found that reducing OIP5-AS1 expression or increasing miR-137 expression controlled the proliferation, invasion and migration of CC cells, promoting the apoptosis rate of tumor cells by regulating the expression of apoptosis-related proteins.
OIP5-AS1 is highly expressed in CC, which contributes to regulation of the biological behavior of CC cells as well as drug resistance to L-OHP in CC cells via mediation of miR-137 expression.
This study reveals the mechanism of OIP5-AS1 in drug resistance to L-OHP in CC cells, which provides a new method to improve the sensitivity of CC cells to L-OHP.