Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.3030
Peer-review started: April 14, 2018
First decision: May 21, 2018
Revised: June 15, 2018
Accepted: June 25, 2018
Article in press: June 25, 2018
Published online: July 21, 2018
The long-term effectiveness of endoscopic resection for small gastric gastrointestinal stromal tumors originating from the muscularis propria layer (MP-GISTs) still remains debatable.
A larger sample size with a longer follow-up period were included to assess the long-term safety and efficacy of ER for gastric MP-GIST
Evaluate the long-term efficacy of ER for small gastric gastrointestinal stromal tumors originating from the muscularis propria layer.
We retrospectively analyzed 229 consecutive patients with gastric MP-GISTs who underwent ER with a follow-up at least 36 mo, between June 2005 and February 2015. The main outcome measurements included complete resection rate, complications, and long-term follow-up outcomes.
The outcomes showed that 225 patients were actively followed-up. The remaining 4 patients were lost because of unrelated death. During the follow-up period, no residual, recurrent lesions, or distant metastasis were detected in any patients.
Endoscopic resection seems to be an effective and safe method for gastric MP-GISTs ≤ 4.0 cm, and for some intermediate or high risk GISTs, adjuvant therapy might be required to reduce the risk of recurrence or metastasis.
Endoscopic resection might be an effective and safe therapeutic method for patients with gastric MP-GISTs ≤ 4.0 cm, and for some patients with intermediate or high risk GISTs, adjuvant therapy (imatinib mesylate, etc.) and/or additional surgery might be required to reduce the risk of recurrence.