Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma
Kenichi Yoshikawa, Akiyoshi Kinoshita, Yuki Hirose, Keiko Shibata, Takafumi Akasu, Noriko Hagiwara, Takeharu Yokota, Nami Imai, Akira Iwaku, Go Kobayashi, Hirohiko Kobayashi, Nao Fushiya, Hiroyuki Kijima, Kazuhiko Koike, Haruka Kaneyama, Keiichi Ikeda, Masayuki Saruta
Kenichi Yoshikawa, Akiyoshi Kinoshita, Yuki Hirose, Keiko Shibata, Takafumi Akasu, Noriko Hagiwara, Takeharu Yokota, Nami Imai, Akira Iwaku, Go Kobayashi, Hirohiko Kobayashi, Nao Fushiya, Hiroyuki Kijima, Kazuhiko Koike, Division of Gastroenterology and Hepatology, Internal Medicine, Jikei University Daisan Hospital, Tokyo 201-8601, Japan
Haruka Kaneyama, Keiichi Ikeda, Department of Endoscopy, Jikei University Daisan Hospital, Tokyo 201-8601, Japan
Masayuki Saruta, Division of Gastroenterology and Hepatology, Internal Medicine, Jikei University School of Medicine, Tokyo 105-8471, Japan
Author contributions: All authors contributed equally to this work; Yoshikawa K and Kanayama H provided the treatment; Yoshikawa K analyzed the data and wrote the manuscript’s text; Kinoshita A wrote the supplementary information; all of the authors discussed the results and commented on the manuscript at all stages.
Informed consent statement: We received patient consent with regard to this manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kenichi Yoshikawa, MD, PhD, Doctor, Staff Physician, Division of Gastroenterology and Hepatology, Internal Medicine, Jikei University Daisan Hospital, 4-11-1 Izumihon-cho, Komae-shi, Tokyo 201-8601, Japan. kyoshikawa@jikei.ac.jp
Telephone: +81-3-34801151 Fax: +81-3-34303611
Received: September 14, 2017
Peer-review started: September 15, 2017
First decision: October 10, 2017
Revised: October 25, 2017
Accepted: November 1, 2017
Article in press: November 1, 2017
Published online: December 7, 2017
ARTICLE HIGHLIGHTS
Case characteristics
A Japanese woman was asymptomatic, and the disease was diagnosed as a result of regular upper gastrointestinal endoscopy.
Clinical diagnosis
The authors diagnosed adenoid cystic carcinoma of the esophagus (EACC).
Differential diagnosis
The diseases to be considered are squamous cell carcinoma (SCC) and gastrointestinal stromal tumor (GIST), which can be estimated by total biopsy.
Laboratory diagnosis
The patient had nothing particular changeincluding hemoglobin and tumor marker.
Imaging diagnosis
Computed tomography scan showed no morphological changes.
Pathological diagnosis
Tumor cell proliferation was primarily submucosal and myoepithelial differentiation was confirmed with immunostaining
Treatment
The patient received endoscopic submucosal dissection (ESD).
Related reports
There is no other case report of ESD treatment for EACC. There are reports of cases with incisional enucleation, surgery, chemotherapy, and radiation therapy.
Term explanation
EACC is a rare tumor, that may be confused with SCC and basaloid-squamous cell carcinoma. There is limited data regarding the frequency of metastasis, and the prognosis of patients with this tumor is poor.
Experiences and lessons
This is the first report of the use of ESD for the treatment of a patient with EACC. ESD may represent an additional treatment option for patients with this disease.
