Xia HHX, Lam SK, Wong WM, Hu WHC, Lai KC, Wong SH, Leung SY, Yuen ST, Wright NA, Wong BCY. Antralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role? World J Gastroenterol 2003; 9(6): 1265-1269 [PMID: 12800237 DOI: 10.3748/wjg.v9.i6.1265]
Corresponding Author of This Article
Dr Benjamin CY Wong, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. bcywong@hku.hk
Article-Type of This Article
H. Pylori
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World J Gastroenterol. Jun 15, 2003; 9(6): 1265-1269 Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1265
Antralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role?
Harry Hua-Xinag Xia, Shiu Kum Lam, Wai Man Wong, Wayne Hsing Cheng Hu, Kam Chuen Lai, Sau Hing Wong, Suet Yi Leung, Siu Tsan Yuen, Nicholas A. Wright, Benjamin Chun-Yu Wong
Harry Hua-Xinag Xia, Shiu Kum Lam, Wai Man Wong, Wayne Hsing Cheng Hu, Kam Chuen Lai, Sau Hing Wong, Benjamin Chun-Yu Wong, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
Suet Yi Leung, Siu Tsan Yuen, Department of Pathology, The University of Hong Kong, Hong Kong SAR, China
Nicholas A. Wright, Histopathology Unit, London Research Institute, Cancer Research, UK
Author contributions: All authors contributed equally to the work.
Supported by the Seed Funding for Basic Research 2001 (301/01), The University of Hong Kong, and a competitive earmarked research grant from the Research Grants Council of Hong Kong Special Administrative Region, China (HKU7318/01M) to HH-X Xia
Correspondence to: Dr Benjamin CY Wong, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. bcywong@hku.hk
Telephone: +852-28554541 Fax: +852-28725828
Received: March 4, 2003 Revised: March 6, 2003 Accepted: March 8, 2003 Published online: June 15, 2003
Abstract
AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances.
METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole.
RESULTS: Patients with index ulcers in the incisura, body or fundus (n = 116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93% vs 60%, OR = 8.95, 95%CI: 2.47-32.4, P = 0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93% to 61%, P = 0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.
CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
