Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1208
Revised: March 4, 2003
Accepted: March 16, 2003
Published online: June 15, 2003
AIM: To investigate the relationship between transcatheter arterial embolization (TAE) and pulmonary metastasis in subjects with hepatocellular carcinoma (HCC).
METHODS: A total of 287 patients with HCC followed up for more than 1 wk were included. 102 patients underwent transcatheter arterial embolization (TAE group) and 185 received conservative treatment (control group). The patients' chest X-rays and chest CT scans were examined for pulmonary metastasis.
RESULTS: Patients with TAE had a median survival of 19.3 mo while that of the control group was only 10.0 mo (P < 0.05). Pulmonary metastasis occurred in 14 (13.7%) patients in the TAE group and 14 (7.6%) patients in the control group, there was no significant difference (P > 0.05). The 1-year, 2-year and 5-year cumulative incidence of pulmonary metastasis was 11.8%, 17.6% and 24.0% in the TAE group and 7.0%, 13.0% and 21.7% in the control group, respectively (P > 0.05). On the univariate analysis, tumor size, abnormal serum alanine aminotransferase levels and heterogeneity on sonography were significantly associated with pulmonary metastasis. However, on the multivariate analysis, only tumor size was significantly predictive of pulmonary metastasis.
CONCLUSION: TAE is effective on prolonging survival of patients with HCC. It does not significantly increase the risk of pulmonary metastasis. Tumor size is the only significant predictive factor associated with lung metastasis.