Basic Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 15, 2003; 9(5): 1051-1053
Published online May 15, 2003. doi: 10.3748/wjg.v9.i5.1051
Effects of two methods of reconstruction of digestive tract after total gastrectomy on gastrointestinal motility in rats
Xin-Yu Qin, Yong Lei, Feng-Lin Liu
Xin-Yu Qin, Yong Lei, Feng-Lin Liu, Department of General Surgery, ZhongShan Hospital, Fudan University, Shanghai 200032, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30070738
Correspondence to: Professor Xin-Yu Qin, Department of General Surgery, ZhongShan Hospital, 180 Fenglin Road, Shanghai 200032, China.
Telephone: +86-21-64037287 Fax: +86-21-64038472
Received: October 9, 2002
Revised: October 23, 2002
Accepted: November 4, 2002
Published online: May 15, 2003

AIM: To compare the effects of Roux-en-Y and jejunum interposition reconstruction procedures after total gastrectomy on intestinal motility.

METHODS: Fifty male Sprague-Dawley rats were randomly divided into 5 groups: the control group (C), the laparotomy group (L), the jejunal transection group (JT) where the jejunum was transected 10 cm distal from the Treitz ligament and anastomosed, the Roux-en-Y group (RY) and the jejunal interposition group (JI) after total gastrectomy. To evaluate intestinal transit, the animals were given 0.1 ml Evans Blue solution through an orogastric tube. The rats were executed by CO2 inhalation 30 minutes later and the intestinal transmit was determined as the distance between the site of esophageojejunal anastomosis and the most distal site of small intestine colored with blue.

RESULTS: One month after operation, the body weight of rats among JI and RY were almost identical (274.6 ± 9.5 vs 270.4 ± 10.6, P > 0.05), but were significantly lighter than those of JT and L group. Four months after the operation, the body weight in the JI group increased compared to the preoperative level (345.2 ± 15.7 g vs 299.5 ± 8.3 g, P < 0.01). However, the body weight of RY group decreased compared to preoperative (255.1 ± 11.3 g vs 295.0 ± 12.0 g, P < 0.01). The difference was more significant at six months postoperative. Small bowel transmit time in RY was slower than that in JI group and C group (P < 0.01).

CONCLUSION: Changes of body weight and intestinal motility in JI group are less influenced than in RY group.

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