Yi J, Wang ZW, Cang H, Chen YY, Zhao R, Yu BM, Tang XM. p16 gene methylation in colorectal cancers associated with Duke′s staging. World J Gastroenterol 2001; 7(5): 722-725
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Dr. Jing Yi, Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing South Road, Shanghai 200025, China. firstname.lastname@example.org
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Jing Yi, Zhi-Wei Wang, Hui Cang, Yu-Ying Chen, Xue-Ming Tang, Department of Cell Biology, Shanghai 200025, China
Ren Zhao, Bao-Ming Yu, Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Author contributions: All authors contributed equally to the work.
Supported by the grants from Ministry of Public Health of China, No.98-1-303 and The Educational Committee of Shanghai, No.2000B02.
Correspondence to: Dr. Jing Yi, Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing South Road, Shanghai 200025, China. email@example.com
Received: April 11, 2001 Revised: June 6, 2001 Accepted: June 20, 2001 Published online: October 15, 2001
AIM: To explore the association of methylation of the CpG island in the promotor of the P16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers.
METHODS: Methylation-specific PCR (MSP) was used to detect P16 methylation of 62 sporadic colorectal cancer specimens.
RESULTS: P16 methylation was detected in 42% of the tumors. Dukes’ staging was associated with P16 methylation status. p16 methylation occurred more frequently in Dukes’ C and D patients (75.9%) than in Dukes’ A and B patients (12.1%).
CONCLUSION: P16 methylation plays a role in the carcinogenes is of a subset of colorectal cancer, and it might be linked to poor prognosis.