Brief Reports
Copyright ©The Author(s) 2001. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 2001; 7(5): 706-709
Published online Oct 15, 2001. doi: 10.3748/wjg.v7.i5.706
Experimental research on TECA-I bioartificial liver support system to treat canines with acute liver failure
Xiao-Ping Chen, Yi-Long Xue, Xin-Jian Li, Zuo-Yun Zhang, Yan-Ling Li, Zhi-Qiang Huang
Yi-Long Xue, Xin-Jian Li, Zuo-Yun Zhang, Yan-Ling Li, Institute of Basic Medical Sciences, Beijing 100853, China
Xiao-Ping Chen, Zhi-Qiang Huang, Department of Hepatobiliary Surgery, PLA General Hospital, Beijing 100853, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Yi-Long Xue, Institute of Basic Medical Sciences, PLA General Hospital, Beijing 100853, China.xueyl@plagh.com.cn
Telephone: +86-10-66937914
Received: May 12, 2001
Revised: June 6, 2001
Accepted: June 20, 2001
Published online: October 15, 2001
Abstract

AIM: To evaluate the efficacy and safety of the TECA-I bioartificial liver support system (BALSS) in treating canines with acute liver failure (ALF).

METHODS: Ten canines with ALF induced by 80% liver resection received BALSS treatment (BALSS group). Blood was perfused through a hollow fiber tube containing 1 × 1010 porcine hepatocytes. Four canines with ALF were treated with BALSS without porcine hepatocytes (control group), and five canines with ALF received drug treatment (drug group). Each treatment lasted 6 h.

RESULTS: BALSS treatment yielded beneficial effects for partial liver resection-induced ALF canines with survival and decreased plasma ammonia, ALT, AST and BIL. There was an obvious decrease in PT level and increase in PA level, and there were no changes in the count of lymphocytes, immunoglobulins (IgA, IgG and IgM) and complement (C3 and C4) levels after BALSS treatment. In contrast, for the canines with ALF in non-hepatocyte BALSS group (control group) and drug group, there were no significant changes in ammonia, ALT, AST, BIL, PT and PA levels. ALF canines in BALSS group, control group and drug group lived respectively an average time of 108.0 h ± 12.0 h, 24.0 h ± 6.0 h and 20.4 h ± 6.4 h, and three canines with ALF survived in BALSS group.

CONCLUSION: TECA-I BALSS is efficacious and safe for ALF canines induced by parcial liver resection.

Keywords: liver, artificial; liver failure, acute/surgery; liver failure, acute/physiopathology; liver failure, acute/immunology