Abstracts
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 119-119
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.119
Relationship of traditional Chinese medicine and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in patients with gastric cancer and precancerous lessions
Wan-Dai Zhang, Xiao-Hu Wang, Jin-Zhang Zeng, Ya-Li Zhang, Yong Sun
Wan-Dai Zhang, Xiao-Hu Wang, Jin-Zhang Zeng, Ya-Li Zhang, Yong Sun, PLA Institute of Digestive Diseases, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Supported by the 95’ Foundation of Chinese PLA for tackling key problem, No. 96Z029
Correspondence to: Dr. Wan-Dai Zhang, Professor, PLA Institute of Digestive Diseases, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, Guangdong Province, China
Telephone: 20-85141212
Received: November 19, 1999
Revised: February 4, 2000
Accepted: March 18, 2000
Published online: September 15, 2000
Abstract

AIM: To study the relationship among typing of Traditional Chinese Medicine (TCM) and Helicobacter pylori infection, expression of oncogene and tumor suppresser genes in gastric cancer and precancerous lessions.

METHODS: According to TCM typing, 120 patients with chronic superficial gastritis, intestinal metaplasia, atypical hyperplasia and gastric cancer were divided into 4 groups: 21 patients with coexistence of cold and heat syndrome (group R), 22 patients with in coordination between the liver and the spleen (group U), 29 patients with deficiency of the spleen-yin (group I) and 48 patients with insufficiency of the spleen yang (group H). Protein expression of c-myc, p21 and p53 were detected immunohistochemically, and Hp were confirmed by modified Giemsa method.

RESULTS: The Hp infection of the group H was significantly higher (72.9%) than that of group R (38.1%, p < 0.01) and group U (40.9%, p < 0.01).Expression of c-myc, p21 and p53 were significantly related to Hp infection and severity of gastric mucosa lesions (group H > group I > group U > group R).

CONCLUSION: Hp infection, expression of oncogene and tumor suppresser genes were related to TCM typing. These parameters were helpful in identification of symptoms and signs and TCM differentiation diagnosis.

Keywords: Helicobacter pylori; Helicobacter infection; stomach neoplasms; Genes, suppressor, Tumor; Oncogenes; Precancerous conditions; Medicine, Chinese traditional