Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.90
Revised: July 26, 1998
Accepted: August 17, 1998
Published online: October 15, 1998
AIM: Study the pharmacokinetics of 7 cephalosporine antibiotics in bile of dogs so as to select appropriate antibiotics for biliary infection.
METHODS: Experimental dogs were administered separately with i.v. cefoperazone, ceftriaxone ceftazidime, cefazolin, ampicillin, cefuroxime, and cefmetazone. Drug concentrations in the bile of the dogs were measured by microbiological method. With 3p87 software, the maximun of concendration (Cm ax), peak time (Tpeak), half-life (T1/2β), clearance (CL), apparent volume of distribution (Va) of each antibiotic were calculated were in bile.
RESULTS: Cmax of cefoperazone was the highest (2464 ng/L); Cmax of ceftriaxone was lower than cefoperazone, but T1/2β ceftriaxone was the longest (6024 min). The Cmax, T1/2β of cefazolin, ceftazidime, ampicillin was lower than the former two but they were significantly higher than cefuroxime ceftriaxone and cefoperazone was the first choice.
CONCLUSION: Among this group of seven antibotics, in the treatment of biliary infection, ceftriaxone is the first choice, and cefoperazone is the second one. cefamedin and ampicillin are not so good as the former two, but they have advantages of low cost, and still can be used in treating biliary infection whild cefuroxime and cefmetazone are not accessable.