Expression of p53, bcl-2, epidermal growth factor receptor in carcinoma and polypoid lesion of the gallbladder and their clinicopathological significance

doi:10.3748/wjg.v4.iSuppl2.87

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Oct 15, 1998 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 87-87
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.87

Expression of p53, bcl-2, epidermal growth factor receptor in carcinoma and polypoid lesion of the gallbladder and their clinicopathological significance

Xiao-Feng Sun, Bao-En Chi, Li Luo

Xiao-Feng Sun, Bao-En Chi, Li Luo, Department of General Surgery, Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Xiao-Feng Sun, Department of General Surgery, Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia, China

Received: June 13, 1998
Revised: July 23, 1998
Accepted: August 14, 1998
Published online: October 15, 1998

Abstract

AIM: To explore the relationship between gallbladder carcinoma and polypoid.

METHODS: The expression of p53, bcl-2, EGFR protein were examined by immunohistochemistry in benign lesions and carcinomas in gallbladder.

RESULTS: The study revealed that overexpression of p53, bcl-2, EGFR protein were detected in 0, 4, 3 in 21 cases of chronic calculus cholecystits , 1, 5, 3, in 20 cases of adenomyomatosis, 7, 11, 7 in 23 cases of adenomas and 16, 14, 11 in 25 cases of adenocarcinomas of the gallbladder respectably. There were significant differences in single or multiple oncogene expression rates between groups but not in chronic cholecystits to adenomyomatosis or in mixed double oncogene expression rate between adenomas and adenocarcinomas.

CONCLUSION: These results suggested that oncogenic changes of p53, bcl-2, EGFR may play a role in tumorigenesis of gallbladder carcinoma, adenomyomatosis is not an important precancerous lesion of gallbladder carcinogenesis but adenomas.

Keywords: Gallbladder neoplasms/pathology, Adenomyomatosis, p53 gene, bcl-2 gene, Gene expression, Epidermal growth factor receptor