Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.72
Revised: August 6, 1998
Accepted: August 23, 1998
Published online: October 15, 1998
AIM: To investigate the concentration changes of plasma nitric oxide (NO) and molitin (MTL) and the relationships between NO, MTL and ulcerative colitis (UC).
METHODS: The plasma concentration of nitrite/nitrate (stable end products of NO, standing for NO) and molitin of 18 patients with UC and 11 control subjects were respectively measured with Cadmiun-reduction chromatography and development process (Greiss) and RIA (Radioimmuno assay). Evaluation was made using Student’s t test for unpaired data and correlative analysis performed. P < 0.05 was considered significant statistically.
RESULTS: The concentration of plasma NO and MTL in control group were 21.34 ± 5.86 μmol/L, 348.42 ± 124.32 ng/L; respectively whereas in UC group were 46.76 ± 10.43 μmol/L, 581.24 ± 176.58 ng/L respectively. The concentration of plas ma NO and MTL in UC groups were significantly higher than those in controls (P < 0.01,P < 0.05,respectively). The concentration change of plasma NO in UC group significantly correlated with the change of MTL (r = 0.482,P < 0.05); there is no significant correlation in control group (r = 0.376,P < 0.20), however.
CONCLUSION: Nitric oxide and molitin are both involved in the pathophysiologic process of ulcerative colitis. Moreover, there may be some positive interactions between NO and MTL in the pathogenesis of UC.