Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.62
Revised: August 9, 1998
Accepted: August 27, 1998
Published online: October 15, 1998
AIM: To observe the effects of jaundice relieving and enzyme reduction by Chinese Medicine compound oriental wormwood injection (COWI) on toxic injury of liver in rats.
METHODS: The toxic liver injury models of rats were induced by intragastric perfusion of α-naphthalin-isothiocyanateyl (75 mg/kg·wk). Then models of rats were treated with COWI of three different doses (5 mL/kg·d, 10 mL/kg·d, 15mL/kg·d, respectively) sc. COWI consisted of oriental wormwood, capejasmine, coptis, gentian, scutellaria and rhubarb. COWI originally has the effects of heat-clearing, detoxication, purging of fire and elimination of dampness. Serum alinine aminotransferase (SALT) and serum total bilirubin (STBIL) were measured at 24 h, 48 h, 72 h respectively after treatment with COWI on toxic injury of liver in rats.
RESULTS: Average levels of SALT and STBIL of treatment groups of three different doses were significantly lower compared with control groups (P < 0.05). The group treated with a dose of 15 mL/kg·d for 72 h achieved the best result comparably.
CONCLUSION: (1) The results demonstrate that COWI have effects of relieving jaundice and reducing SALT. (2) COWI is a treatment of choice for acute icteric hepatitis.