Abstracts
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 62-62
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.62
Experimental research of jaundice relieving and enzyme reduction by Chinese medicine compound oriental wormwood injection on toxic injury of liver in rats
De-Yong Chen, Bo Lei, Hui-Min Li, Su-Gang Zhang, Zhen-Man Wei, Guang-Ming Cai, Jia-Lin Zhang
De-Yong Chen, Third Department, 302 Hospital, Beijing 100039, China
Bo Lei, Hui-Min Li, Su-Gang Zhang, Zhen-Man Wei, Guang-Ming Cai, Department of Drug Research, 302 Hospital, Beijing 100039, China
Jia-Lin Zhang, Department of Drug, 302 Hospital, Beijing 100039, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. De-Yong Chen, Third Department, 302 Hospital, Beijing 100039, China
Received: July 13, 1998
Revised: August 9, 1998
Accepted: August 27, 1998
Published online: October 15, 1998
Abstract

AIM: To observe the effects of jaundice relieving and enzyme reduction by Chinese Medicine compound oriental wormwood injection (COWI) on toxic injury of liver in rats.

METHODS: The toxic liver injury models of rats were induced by intragastric perfusion of α-naphthalin-isothiocyanateyl (75 mg/kg·wk). Then models of rats were treated with COWI of three different doses (5 mL/kg·d, 10 mL/kg·d, 15mL/kg·d, respectively) sc. COWI consisted of oriental wormwood, capejasmine, coptis, gentian, scutellaria and rhubarb. COWI originally has the effects of heat-clearing, detoxication, purging of fire and elimination of dampness. Serum alinine aminotransferase (SALT) and serum total bilirubin (STBIL) were measured at 24 h, 48 h, 72 h respectively after treatment with COWI on toxic injury of liver in rats.

RESULTS: Average levels of SALT and STBIL of treatment groups of three different doses were significantly lower compared with control groups (P < 0.05). The group treated with a dose of 15 mL/kg·d for 72 h achieved the best result comparably.

CONCLUSION: (1) The results demonstrate that COWI have effects of relieving jaundice and reducing SALT. (2) COWI is a treatment of choice for acute icteric hepatitis.

Keywords: Hepatitis, toxic/therapy; Compound oriental wormwood injection; Disease models; Animal