Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.57
Revised: August 27, 1998
Accepted: September 22, 1998
Published online: October 15, 1998
AIM: To study the role of oxygen free radical (OFR) and other inflammatory mediators in acute necrotizing pancreatitis (ANP).
METHODS: ANP model was induced by retrograde injection of 5% sodium taurocholate 2.0 mL/kg, rats were randomly divided into four groups : (1) control group. (2) ANP group, (3) ANP + NS group, (4) ANP + IL-2 group. Changes of SOD and MDA in plasma and pancreatic tissues and serum endotoxin, PLA2 were studied. We also studied the histologic changes of pancreas, liver and lung. The effects of interleukin-2 (IL-2) in the treatment of ANP were observed in this experiment.
RESULTS: Oxygen free radicals were involved in the aggravation of ANP and was associated with the increase of serum endotoxin and PLA2. Those mediators were positively correlated with severe multiple organ damage. The results also suggested that IL-2 can inhibit the overexpression of OFR and endotoxin, and reduce the incidence of multiple organ damage in ANP.
CONCLUSION: OFR might play a major role in the pathogenesis of ANP, and IL-2 might have a potential role in the treatment of ANP.