Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.121
Revised: August 16, 1998
Accepted: September 8, 1998
Published online: October 15, 1998
AIM: To study the sensitivity, specifity and clinical utility of 14C urea breathing test of Helicobacter pylori infection.
METHODS: All the 150 cases (40 cases of chronic gastritis, 30 cases of gastric ulcer, 50 cases of duodenal ulcer, 20 cases of gastric carcinoma 8 cases of polypous gastritis, 2 cases of portal hypertensive gastropathy) were examined by fibrogastroscopy and confirmed by biopsy pathology, 15 cases of duodenal ulcer and 5 cases of gastric ulcer were treated with PPI tetratherapy for 1 mo, then a comparison between the pretreatment and posttreatment was made, 14C-urea was calculated by scintillator.
RESULTS: (1) The Hp infection rates of chronic gastritis duodenal ulcer and gastric ulcer and gastric carcinoma had no difference in statistics with the method of 14C-UBT. (2) There was no difference of 14C-UBT radioactivity value between chronic gastritis and duodenal ulcer, (3) Chronic gastritis accompanied with gastric mucosal erosion atrophy and entero-metaplasia was significantly higher than simple chronic gastritis (t < 0.05). (4) After one-month bactericidal treatment the bactericidal rate reached 100%.
CONCLUSION: 14C-UBT is a sensitive, high effective and specific method for Hp detection.