Qiao GB, Han CL, Jiang RC, Sun CS, Wang Y, Wang YJ. Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi’an. World J Gastroenterol 1998; 4(1): 57-60 [PMID: 11819233 DOI: 10.3748/wjg.v4.i1.57]
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Dr. Gui-Bin Qiao, Department of Thoracic and Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, PLA, Guangzhou 510010, Guangdong Province,China
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World J Gastroenterol. Feb 15, 1998; 4(1): 57-60 Published online Feb 15, 1998. doi: 10.3748/wjg.v4.i1.57
Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi’an
Gui-Bin Qiao, Cheng-Long Han, Ren-Chao Jiang, Chang-Sheng Sun, Yan Wang, Yun-Jie Wang
Gui-Bin Qiao, Ren-Chao Jiang, Department of Thoracic and Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, PLA, Guangzhou 510010, Guangdong Province, China
Cheng-Long Han, Laboratory of Cellular Oncology, National Cancer Institute, USA
Chang-Sheng Sun, Yan Wang, Yun-Jie Wang, Department of Epidemiology, the Fourth Military Medical University, Xi’an 710000, Shaanxi Province, China
Gui-Bin Qiao, male, born on 1969-07-20 in Taiyuan, Shaanxi Province, graduated from the Fourth Military Medical University, as a postgraduate in 1996, specialized in research and treatment of thoracic diseases, having more than 10 papers and 3 books published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Gui-Bin Qiao, Department of Thoracic and Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, PLA, Guangzhou 510010, Guangdong Province,China
Telephone: +86-20-86694772
Received: January 2, 1997 Revised: March 26, 1997 Accepted: April 20, 1997 Published online: February 15, 1998
Abstract
AIM: To investigate the risk factors of esophageal cancer (EC) in urban areas of Xi’an and to determine the association between overexpression of P53 and these risk factors.
METHODS: All cases (89) and controls (97) were permanent residents in urban areas of Xi’an, all cases of primary EC had been histologically confirmed, controls were inpatients with non-cancer and nonsmoking-related disease. Cancer tissues and tissues adjacent to the cancer of 65 cases and 24 available normal esophageal tissues of controls were detected for P53 overexpression by the immunohistochemical method.
RESULTS: The smoking and familial history of cancer were significantly associated with EC in Xi’an inhabitants. The laboratory assay indicated that P53 positive stain in EC was 50.0%(34/65)and 6.1%(4/65) in tissues adjacent to the cancer, but no positive stain was found in normal esophageal tissues of controls. The results showed that P53 overexpression in EC was closely related to smoking and cases with familial history of cancer.
CONCLUSION: Smoking and familial cancer history were important risk factors for EC,and the alteration of P53 gene may be due to smoking and inheritance factors.
