Original Articles
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 1998; 4(1): 24-27
Published online Feb 15, 1998. doi: 10.3748/wjg.v4.i1.24
Clinical and experimental study of therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions
Xu-Chen Zhang, Rui-Feng Gao, Bing-Qing Li, Lian-Sheng Ma, Li-Xin Mei, Yu-Zhen Wu, Feng-Qin Liu, Zheng-Lin Lian
Xu-Chen Zhang, Li-Xin Mei, Department of Pathology, Chengde Medical College, Chengde 067000, Hebei Province, China
Rui-Feng Gao, Yu-Zhen Wu, Feng-Qin Liu, Zheng-Lin Lian, Bing-Qing Li, Department of Gastroenterology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China
Lian-Sheng Ma, Research and Treatment Center of Gastroenterology of Taiyuan, Taiyuan 030001, Shanxi Province, China
Xu-Chen Zhang, male, born on 1966-2-26 in Ding County, Hebei Province, graduated from Beijing University of Traditional Chinese Medicine, Lecturer of pathology, having 26 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Xu-Chen Zhang, Department of Pathology, Chengde Medical College, Chengde 067000, Hebei Province, China
Telephone: +86-314-2063776
Received: August 2, 1997
Revised: September 20, 1997
Accepted: October 10, 1997
Published online: February 15, 1998
Abstract

AIMS: To observe the therapeutic effect of Wei-xibaonizhuan pills on gastric precancerous lesions.

METHODS: Thirty patients with gastric precancerous lesions were treated with Weixibaonizhuan pills for 3 months. Of the 36 cases, 13 (36.1%) were mild atrophic gastritis, 14 (38.9%) moderate atrophic gastritis and 9 (25.0%) severe atrophic gastritis; among them 22 (61.1%) and 27 cases (75.0%) were accompanied with intestinal metaplasia (IM) and dysplasia (DYS) respectively. Of the 36 patients, 20 were men and 16 women, aged from 30-60 years and those aged 30-59 years accounted for 61.1%. The course of disease ranged from 3 months to 21 years, and 20 (55.6%) of them had a course of 5-10 years. The clinical manifestations were fullness of the abdomen (31 cases),abdominalgia (27 cases), anorexia (30 cases), gas eructation (26 cases), acid regurgitation (6 cases) and loose stool (9 cases). When treatment ended, the improvement of patients’ clinical symptoms, atrophy of gastric mucosa, IM and DYS were analysed.

RESULTS: After 3 months’ treatment with Wei-xibaonizhuan pills,7 cases recovered, 11 cases were much improved, 13 cases showed some improvement, and 5 cases were ineffective; the total rate of symptomatic improvement was 86.1%. Of the 13 cases with mild atrophic gastritis, 11 cases changed into superficial gastritis, and 2 cases had no changes. Of the 14 cases of moderate atrophic gastritis, 4 cases changed into superficial gastritis, 7 cases changed into mild atrophic gastritis, and 3 cases had no changes. Five of 9 cases of severe atrophic gastritis were reduced to moderate atrophic gastritis, and 4 cases had no changes. The total effective rate was 77.8% in chronic atrophic gastritis. Of the 9 cases with mild IM, IM disappeared in 6 cases and 3 showed no change. Of the 10 cases with moderate IM, it disappeared in 2 cases, 5 cases changed to mild IM, and 3 cases had no change. One of the 4 cases of severe IM changed to moderate IM and 3 had no change. The total effective rate was 63.6% in IM. Of the 16 cases of mild DYS, 11 cases showed disappearance of DYS and 5 had no change. In 9 cases of moderate DYS, 2 showed disappearance, 5 changed to mild DYS and 2 had no change. Two cases of severe DYS, both showed no change. The total effective rate was 66.7% in DYS. Before treatment, the I, II, III and IV degree positive expressions of CEA were present in 13, 12, 9 and 2 cases, respectively, whereas after treatment, the positive expressions were present in 25, 7, 3 and 1, respectively. Before treatment, the I, II, III and IV degree positive expressions of PCNA were present in 16, 11, 10 and 4 respectively, but after treatment, they were present in 21, 9, 5 and 1 respectively. In short, the positive expressions of CEA and PCNA of gastric mucosa were significantly decreased after treatment (P < 0.01).

CONCLUSION: Weixibaonizhuan pill has a therapeutic effect in gastric precancerous lesions.

Keywords: Weixibaonizhuan pills, stomach neoplasm/TCM therapy, precancerous conditions, gastric mucosa, Chinese herbal