Sun YT, Zhou F, Zheng HX, Xiao JD. Clinical efficacy and mechanism of Bletilla striata and Chinese herbal compounds in treatment of peptic ulcer. World J Gastroenterol 2025; 31(30): 110145 [DOI: 10.3748/wjg.v31.i30.110145]
Corresponding Author of This Article
Hong-Xin Zheng, PhD, Professor, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang 110032, Liaoning Province, China. zhenghx2002@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yi-Tong Sun, Fang Zhou, The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Hong-Xin Zheng, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Jing-Dong Xiao, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Co-corresponding authors: Hong-Xin Zheng and Jing-Dong Xiao.
Author contributions: Sun YT and Zhou F drafted the manuscript; Zheng HX and Xiao JD revised and approved the final version of the article, and both authors contribute equally to this study as co-corresponding authors.
Supported by National Science and Technology Major Project, No. 2024ZD0521002; The Innovation Team Project of Traditional Chinese Medicine of Liaoning Province, No. LNZYYCXTD-CCCX-003; General Program of the National Natural Science Foundation of China, No. 82074296; and Construction Project of Inheritance Studios of Famous Chinese Medicine Experts in China, No. [2022] No. 75.
Conflict-of-interest statement: Authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Xin Zheng, PhD, Professor, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang 110032, Liaoning Province, China. zhenghx2002@126.com
Received: June 5, 2025 Revised: July 3, 2025 Accepted: July 14, 2025 Published online: August 14, 2025 Processing time: 62 Days and 22.9 Hours
Abstract
Peptic ulcer (PU) is characterized by inflammation, necrosis, and erosion of the gastrointestinal mucosa caused by various pathogenic factors, leading to ulcer formation. The stomach and duodenum are the most commonly affected sites. Bletilla striata, a traditional Chinese medicinal herb, contains diverse chemical constituents and exhibits multiple pharmacological effects. As a key component in various traditional Chinese medicine compound formulations, it has demonstrated notable clinical efficacy. Moreover, it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases. This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs, drawing from ancient medical literature and traditional formula applications to provide support for clinical use.
Core Tip: Bletilla striata has shown notable effects in the treatment of peptic ulcers. Clinical studies indicate that it can not only alleviate ulcer symptoms but also promote ulcer healing and enhance patients’ quality of life. The mechanisms of action of Bletilla striata and its traditional Chinese medicine compound formulations require further investigation and are believed to involve multiple processes, including anti-inflammatory activity, antioxidant effects, and promotion of gastric mucosal repair.
