Nilanka Wickramasinghe, Department of Physiology, Faculty of Medicine, University of Colombo, Colombo 00800, Western Province, Sri Lanka
Niranga Manjuri Devanarayana, Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Western Province, Sri Lanka
Author contributions: Wickramasinghe N and Devanarayana NM wrote the main manuscript text and prepared figures and tables.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Niranga Manjuri Devanarayana, MBBS, MD, PhD, Professor, Department of Physiology, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Western Province, Sri Lanka. niranga@kln.ac.lk
Received: June 27, 2024 Revised: October 26, 2024 Accepted: November 11, 2024 Published online: January 7, 2025 Processing time: 165 Days and 6.8 Hours
Abstract
Gastroesophageal reflux disease (GERD) poses a substantial global health challenge, with prevalence rates exhibiting geographical variation. Despite its widespread recognition, the exact prevalence and associated risk factors remain elusive. This article comprehensively analyzed the global burden of GERD, shedding light on its risk factors, underlying pathophysiological mechanisms, current diagnostic modalities, evolving management strategies tailored to diverse patient profiles, and complex determinants contributing to treatment failures. A deeper comprehension of GERD is achieved by dissecting these intricate facets, paving the way for enhanced clinical management and improved patient outcomes.
Core Tip: To enhance physicians' understanding of gastroesophageal reflux disease (GERD), it is crucial to comprehensively examine its risk factors, underlying pathophysiological mechanisms, current diagnostic modalities, and diverse management strategies tailored to various patient profiles. Additionally, identifying the determinants contributing to treatment failures is essential. By delving into these aspects, healthcare providers can better address GERD, a significant global health challenge.
