Original Research
Copyright ©The Author(s) 1997. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 1997; 3(4): 246-248
Published online Dec 15, 1997. doi: 10.3748/wjg.v3.i4.246
Treatment of cancerous ascites and radical gastrectomy with intraperitoneal hyperthermic double-distilled water and cis-diaminodichloro-platinum perfusion
Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Jian-San Tan
Zhi-Xing Chen, Jia-Ping Chen, Zhong Chen, De-Shu Peng, Ji-Xiang Zhen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China
Jian-San Tan, Department of Pathology, Fourth Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China
Zhi-Xing Chen, male, born on 1961-12-25 in Langzhong City, Sichuan Province, graduated from the West China University of Medical Sciences as a postgraduate in 1993, currently Attending Surgeon, mainly devoted to the studies of diagnosis and treatment of gastroenteric tumors, having 10 papers published.
Author contributions: All authors contributed equally to the work.
Supported by The Sichuan Provincial Health Bureau (94F0132).
Correspondence to: Dr. Zhi-Xing Chen, Department of Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China
Telephone: +86-28-5551255-26808
Received: July 20, 1996
Revised: September 9, 1997
Accepted: October 28, 1997
Published online: December 15, 1997
Abstract

AIM: To study the therapeutic effect of intraperitoneal hyperthermic double-distilled water and cis-diaminodichloro-platinum (DDP) perfusion for cancerous ascites and radical gastrectomy.

METHODS: LACA mice were injected peritoneally with H22 cancer cells (2 × 107 tumor cells). Five days later, the mice received treatments with either intraperitoneal perfusion of 37 °C isotonic fluid (group I), or 43 °C simple hyperthermic double-distilled water (group II), isotonic fluid (group III), DDP (group IV) or a combination of the hyperthermic double-distilled water with DDP (group V). A clinical experiment with intraperitoneal hyperthermic double-distilled water perfusion with DDP was carried out from September 1991 through September 1993 with 32 advanced gastric cancer patients who had undergone radical gastrectomy.

RESULTS: In comparison with the untreated control group of cancer cell-bearing LACA mice, the mice in all treatment groups showed near complete obliteration of cancer cells in the peritoneal cavity, markedly reduced ascites, prolonged survival times, and reduced growth of peritoneal cancerous nodes. In the clinical experiment, all 32 patients with advanced carcinoma had achieved satisfactory results at the 1-year follow-up, but had unsatisfactory results at the 2-year follow-up.

CONCLUSION: The intraperitoneal hyperthermic double-distilled water perfusion with DDP inhibited the occurrence of ascites in LACA mice bearing cancer cells, and prolonged the lifetime of patients with gastric cancer who had undergone radical gastrectomy.

Keywords: Gastrectomy; Stomach neoplasms; Ascites; Cis-diaminodichloro-platinum; Perfusion