Chen K, Jiao DA, Zheng S, Zhou L, Yu H, Yuan YC, Yao KY, Ma XY, Zhang Y. Diagnostic value of occult fecal blood testing for colorectal cancer screening. World J Gastroenterol 1997; 3(3): 166-168 [PMID: 27239137 DOI: 10.3748/wjg.v3.i3.166]
Corresponding Author of This Article
Dr. Kun Chen, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China
Article-Type of This Article
Original Research
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World J Gastroenterol. Sep 15, 1997; 3(3): 166-168 Published online Sep 15, 1997. doi: 10.3748/wjg.v3.i3.166
Diagnostic value of occult fecal blood testing for colorectal cancer screening
Kun Chen, Deng-Ao Jiao, Shu Zheng, Lun Zhou, Hai Yu, Ya-Chang Yuan, Kai-Yan Yao, Xing-Yuan Ma, Yang Zhang
Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China
Shu Zheng, Lun Zhou, Hai Yu, Institute of Cancer Research, Zhejiang Medical University, Hangzhou, Zhejiang Province, China
Ya-Chang Yuan, Kai-Yan Yao, Xing-Yuan Ma, Institute of Cancer Prevention & Control, Jianshan, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National “8th 5-year” Science and Technology Development Projects (No.85-914-01).
Correspondence to: Dr. Kun Chen, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China
Telephone: +86-571-7022700-570
Received: October 26, 1996 Revised: December 21, 1996 Accepted: January 19, 1997 Published online: September 15, 1997
Abstract
AIM: To evaluate the diagnostic value of occult fecal blood testing in mass colorectal cancer screening.
METHODS: A reverse passive hemagglutination reaction fecal occult blood test (RPHA-FOBT) and colorectal cancer risk factor quantitative method were used as preliminary screening for colorectal cancer. A 60-cm fiber optic colonoscopy was used to validate the preliminary screen and was used to detect colorectal cancer in a community of 75813 subjects.
RESULTS: Compared to the 60-cm fiber optic colonoscopy as a standard reference, FOBT has a sensitivity of 41.9%, specificity of 95.8%, Youden′s index of 0.38, and positive predictive value of 0.68%. These results increased with subject age from the first detection. A 3-year follow up in the target mass showed that all new cases had initially been FOBT-negative.
CONCLUSION: The value of FOBT as an indicator of colorectal cancer in mass screening is limited.
