Published online Sep 7, 2022. doi: 10.3748/wjg.v28.i33.4834
Peer-review started: March 14, 2022
First decision: May 9, 2022
Revised: May 23, 2022
Accepted: August 6, 2022
Article in press: August 6, 2022
Published online: September 7, 2022
Patients with inflammatory bowel disease (IBD) are prone to several nutritional deficiencies. However, data are lacking on vitamin C deficiency in Crohn’s disease (CD) and ulcerative colitis (UC) patients, as well as the impact of clinical, bio
To determine proportions and factors associated with vitamin C deficiency in CD and UC patients.
In this retrospective study, we obtained clinical, laboratory and endoscopic data from CD and UC patients presenting to the IBD clinic at a single tertiary care center from 2014 to 2019. All patients had an available plasma vitamin C level. Of 353 subjects who met initial search criteria using a cohort discovery tool, 301 ultimately met criteria for inclusion in the study. The primary aim described vitamin C deficiency (≤ 11.4 μmol/L) rates in IBD. Secondary analyses compared proportions with deficiency between active and inactive IBD. Multivariate logistic regression analysis evaluated factors associated with deficiency.
Of 301 IBD patients, 21.6% had deficiency, including 24.4% of CD patients and 16.0% of UC patients. Patients with elevated C-reactive protein (CRP) (39.1% vs 16.9%, P < 0.001) and fecal calprotectin (50.0% vs 20.0%, P = 0.009) had signifi
Vitamin C deficiency was common in IBD. Patients with elevated inflammatory markers and penetrating disease had higher rates of vitamin C deficiency.
Core Tip: This study aimed to determine proportions and factors associated with vitamin C deficiency in inflammatory bowel disease (IBD) patients. In 301 patients, 21.6% had vitamin C deficiency, including 24.4% of Crohn’s disease and 16.0% of ulcerative colitis patients. Patients with elevated C-reactive protein (39.1% vs 16.9%) and fecal calprotectin (50.0% vs 20.0%) had higher proportions of deficiency compared to those without, as did patients with penetrating disease (36.2% vs 20.8%). This study provides the largest data on vitamin C deficiency in IBD, and demonstrates that deficiency is common in this population, particularly those with markers of active luminal or penetrating disease.