Published online Nov 21, 2021. doi: 10.3748/wjg.v27.i43.7546
Peer-review started: May 23, 2021
First decision: June 12, 2021
Revised: July 19, 2021
Accepted: October 27, 2021
Article in press: October 27, 2021
Published online: November 21, 2021
Circulating tumor cells (CTCs) and survivin are indicators for tumor stage and metastasis, as well as epitheliomesenchymal transition, in various cancers, including hepatocellular cancer (HCC).
To explore the potential of survivin-positive CTCs, specifically, as a marker for tumor progression in HCC patients.
We examined the survivin expression pattern in CTCs obtained from 179 HCC patients, and investigated the in vitro effects of survivin silencing and overexpression on the proliferation and invasion of HCC cells. CTC count and survivin expression in patient samples were examined using RNA in situ hybridization.
All 179 patients were positive for CTC markers, and 94.41% of the CTCs were positive for survivin. The CTC and survivin-positive CTC counts were signi
Survivin shows upregulated expression (indicative of anti-apoptotic effects) in HCC. Thus, survivin-positive CTCs are promising as a predictor of HCC prognosis and metastasis, and their accurate measurement may be useful for the management of this cancer.
Core Tip: This study first analyzed surviving-positive circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC). The levels of survivin expression in different CTCs were significantly different. The rates of moderate and high expression in the mesenchymal and hybrid CTCs were significantly higher than those in the epithelial CTCs. Survivin overexpression induced HCC cell proliferation, promoted their invasive ability, and reduced apoptosis. The expression of survivin in mesen