Published online Sep 21, 2021. doi: 10.3748/wjg.v27.i35.5851
Peer-review started: January 28, 2021
First decision: June 14, 2021
Revised: July 14, 2021
Accepted: August 23, 2021
Article in press: August 23, 2021
Published online: September 21, 2021
Pancreatic cancer is one of the solid tumors with the worst prognosis. Five-year survival rate is less than 10%. Surgical resection is the only potentially curative treatment, but the tumor is often diagnosed at an advanced stage of the disease and surgery could be performed in a very limited number of patients. Moreover, surgery is still associated with high post-operative morbidity, while other therapies still offer very disappointing results. This article reviews every aspect of pancreatic cancer, focusing on the elements that can improve prognosis. It was written with the aim of describing everything you need to know in 2021 in order to face this difficult challenge.
Core Tip: Pancreatic cancer is a very dangerous enemy and the results are still very unsatisfactory. But we have not given up. Research is running fast on many paths, without losing its enthusiasm.The number of articles published on this subject in the last two years is impressive. I have tried to summarize all the most significant data from the different lines of research, ranging from screening and early diagnosis to new developments in surgery and associated therapies. I hope I have succeeded in the task of describing as comprehensively as possible the most promising fields of research available to us today, in order to achieve the improved results we desire.