Published online Jul 28, 2021. doi: 10.3748/wjg.v27.i28.4493
Peer-review started: January 28, 2021
First decision: March 29, 2021
Revised: April 11, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: July 28, 2021
Gastrointestinal cancers occur in a total of eight different locations, each of them with a different standard of care. This article is not an exhaustive review of what has been published in 2020. We have concentrated on the thirteen phase III randomized studies that are practice-changing. All these studies are oral presentations which have been given in one of the four major oncology congresses, namely American Society of Clinical Oncology (ASCO), ASCO gastrointestinal (GI), European Society of Medical Oncology (ESMO) and ESMO-GI. We provide a concise view of these major trials and their main outcomes, and put these results into context.
Core Tip: Gastrointestinal cancers are one of the most frequent cancers and a leading cause of cancer deaths worldwide. Gastroenterologists, hepatologists and visceral surgeons interact daily with these patients. Bringing the community up to speed with new treatment paradigms in gastrointestinal oncology could improve patient care. Here we provide a clear, comprehensive and short overview of the most important practice changing trials from 2020.