Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.4160
Peer-review started: January 29, 2021
First decision: May 13, 2021
Revised: May 27, 2021
Accepted: June 17, 2021
Article in press: June 17, 2021
Published online: July 14, 2021
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that causes coronavirus disease-2019 (COVID-19) has provoked a global pandemic, mainly affecting the respiratory tract; however, a percentage of infected individuals can develop gastrointestinal (GI) symptoms. Some studies describe the development of GI symptoms and how they affect the progression of COVID-19. In this review, we summarize the main mechanisms associated with gut damage during infection by SARS-CoV-2 as well as other organs such as the liver and pancreas. Not only are host factors associated with severe COVID-19 but intestinal microbiota dysbiosis is also observed in patients with severe disease.
Core Tip: Coronavirus disease-2019 (COVID-19) affects not only the respiratory systems but also gastrointestinal (GI) system and function of others organs. Until now, the mechanism of infection that severe acute respiratory syndrome, coronavirus 2 uses is not fully known. GI symptoms are rare but had great relevance in the severity of disease. We summarize the main known mechanisms that are associated with intestinal damage, and the knowledge that is had about the impact of COVID-19 on the liver and pancreas.