Lu ZY, Zhao DY. Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report. World J Gastroenterol 2021; 27(25): 3940-3947 [PMID: 34321856 DOI: 10.3748/wjg.v27.i25.3940]
Corresponding Author of This Article
Dun-Yong Zhao, MM, Associate Chief Physician, Department of Gastroenterology, Institute of Digestive, Southwest Hospital, Army Military Medical University, No. 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China. 872083291@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 7, 2021; 27(25): 3940-3947 Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3940
Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: A case report
Zhi-Yu Lu, Dun-Yong Zhao
Zhi-Yu Lu, Dun-Yong Zhao, Departments of Gastroenterology, Institute of Digestive, Southwest Hospital, Army Military Medical University, Chongqing 400038, China
Author contributions: Lu ZY reviewed the literature and was responsible for manuscript drafting and organization of illustrations and contributed to the interpretation of the imaging findings and endoscopic findings; Zhao DY analyzed and interpreted the pathological findings, immunohistochemical findings, and genetic mutation and was responsible for the revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dun-Yong Zhao, MM, Associate Chief Physician, Department of Gastroenterology, Institute of Digestive, Southwest Hospital, Army Military Medical University, No. 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China. 872083291@qq.com
Received: January 22, 2021 Peer-review started: January 22, 2021 First decision: February 28, 2021 Revised: March 2, 2021 Accepted: April 21, 2021 Article in press: April 21, 2021 Published online: July 7, 2021
Abstract
BACKGROUND
Schwannomas, also known as neurinomas, are tumors that derive from Schwann cells. Gastrointestinal schwannomas are extremely rare, but the stomach is the most common site. Gastric schwannomas are usually asymptomatic. Endoscopy and imaging modalities might offer useful preliminary diagnostic information. However, to diagnose schwannoma, the immunohistochemical positivity for S-100 protein is essential, whereas CD117, CD34, SMA, desmin, and DOG-1 are negative.
CASE SUMMARY
A 45-year-old female was found to have a gastric mass during a medical examination, which was diagnosed as a gastric schwannoma. We performed endoscopic full-thickness resection and endoscopic purse-string suture. Pathology and immunohistochemical staining confirmed the diagnosis of gastric schwannoma through the positivity of S-100 protein. Furthermore, to exclude the misdiagnosis of gastrointestinal stromal tumor, we performed a mutational detection of the c-Kit and PDGFRA genes. Postoperative follow-up revealed that the patient recovered well.
CONCLUSION
Immunohistochemical staining is essential for the diagnosis of schwannoma. Endoscopic full-thickness resection is an effective treatment method for gastric schwannoma.
Core Tip: Schwannomas can occur in any part of the digestive tract but are most common in the stomach. Gastric schwannomas are typically asymptomatic, and it is difficult to make a precise preoperative diagnosis. The final diagnosis of schwannoma is based on immunohistochemical staining. We performed endoscopic full-thickness resection and endoscopic purse-string suture. We report a case diagnosed with gastric schwannoma.
