Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.2963
Peer-review started: February 2, 2021
First decision: February 27, 2021
Revised: March 10, 2021
Accepted: April 21, 2021
Article in press: April 21, 2021
Published online: June 14, 2021
Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. The colorectum is considered the chief target organ of UC, whereas upper gastrointestinal (UGI) tract manifestations are infrequent. Recently, emerging evidence has suggested that UC presents complications in esophageal, stomachic, and duodenal mucosal injuries. However, UC-related UGI tract manifestations are varied and frequently silenced or concealed. Moreover, the endoscopic and microscopic characteristics of UGI tract complicated with UC are nonspecific. Therefore, UGI involvement may be ignored by many clinicians. In addition, no standard criteria have been established for patients with UC who should undergo fibrogastroduodenoscopy. Furthermore, specific treatment recommendations may be needed for patients with UC-associated UGI lesions. Herein, we review the esophageal, gastric, and duodenal mucosal lesions of the UC-associated UGI tract, as well as the potential pathogenesis and therapy.
Core Tip: This is a minireview to summarize the esophageal, gastric, and duodenal mucosal lesions of the ulcerative colitis (UC)-associated upper gastrointestinal (UGI) tract, together with the potential pathogenesis and treatment recommendations. UC-related UGI manifestations are diverse and normally quite or covered by the manifestations of the lower gastrointestinal tract. In addition, the endoscopic and microscopic characteristics of UGI tract complicated with UC are typically unspecified. However, it is very important to identify UC-associated UGI tract diseases. Our research may assist in the diagnosis and monitoring of UC-associated UGI tract diseases.