Published online May 14, 2021. doi: 10.3748/wjg.v27.i18.2090
Peer-review started: January 3, 2021
First decision: January 23, 2021
Revised: February 27, 2021
Accepted: April 5, 2021
Article in press: April 5, 2021
Published online: May 14, 2021
Hepatitis E virus (HEV) is an important cause of repeated waterborne outbreaks of acute hepatitis. Recently, several extrahepatic manifestations (EHMs) have been described in patients with HEV infection. Of these, neurological disorders are the most common EHM associated with HEV. The involvement of both the peripheral nervous system and central nervous system can occur together or in isolation. Patients can present with normal liver function tests, which can often be misleading for physicians. There is a paucity of data on HEV-related neurological manifestations; and these data are mostly described as case reports and case series. In this review, we analyzed data of 163 reported cases of HEV-related neurological disorders. The mechanisms of pathogenesis, clinico-demographic profile, and outcomes of the HEV-related neurological disorders are described in this article. Nerve root and plexus disorder were found to be the most commonly reported disease, followed by meningoencephalitis.
Core Tip: Neurological involvement in patients with hepatitis E virus (HEV) infection is rare. There is a paucity of data on HEV-related neurological manifestations. This review comprehensively describes the mechanisms of pathogenesis, clinico-demographic profile, and outcomes of HEV-related neurological disorders. Nerve root and plexus disorder were the most commonly reported diseases followed by meningoencephalitis. These patients can present with normal liver function tests, which can often be misleading for physicians.