Published online Nov 28, 2020. doi: 10.3748/wjg.v26.i44.7085
Peer-review started: June 25, 2020
First decision: July 28, 2020
Revised: August 26, 2020
Accepted: November 9, 2020
Article in press: November 9, 2020
Published online: November 28, 2020
The present letter to editor is related to Bohra A et al Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care. World J Gastroenterol 2020; 26(18): 2221-2231. Hepatic encephalopathy (HE) is a significant and frequent major decompensating event in cirrhosis. However clinical studies examining the clinical outcome of HE are lacking despite its high prevalence.
Core Tip: This letter to editor serves to add to the ongoing conversation regarding hepatic encephalopathy (HE) and its prognostic significance. The major highlight of this letter is to stress the importance of recognizing other prognostically significant variables such as sarcopenia and active Hepatitis C, which may adversely impact the severity and outcomes of HE. Furthermore it serves to actively encourage future studies in this area.